Across TCGA patient cohorts, PGP protein abundance is significantly associated with the RNA expression of many other genes, with 9,191 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGP-associated genes across cancer lineages are MRPS34, POLR3K, and TEDC2. Each is linked with PGP in more than 6 cancer types. Because this analysis shows association rather than direction, both PGP-to-partner and partner-to-PGP results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGP→partner) and Y-score (partner→PGP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPS34 →	+1.227	+0.307	.004	<.001	3	7
BRCA	POLR3K →	+0.585	+0.283	<.001	<.001	3	6
UCEC	TEDC2 →	+0.806	+0.262	.002	.004	3	6
GBM	PAQR4 →	+0.893	+0.347	<.001	<.001	3	6
BRCA	HAGH →	+0.838	+0.432	<.001	<.001	3	6
BRCA	GFER →	+0.563	+0.227	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,191 associations by consensus.

Exploration

PGP survival (RNA) · tumor vs normal (RNA) · all PGP data types