PGM5P2

Across TCGA pan-cancer cohorts, PGM5P2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PGM5P2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PGM5P2 RNA is repressed in tumor relative to normal tissue. In most cancer types PGM5P2 is over-expressed in tumor, although a few such as KIRC and UCEC show the opposite, repressed pattern.

KIRC, UCEC, and BRCA are the cancer types where PGM5P2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PGM5P2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.398	<.001	9	view →
UCEC	All	All	−1.030	<.001	8	view →
BRCA	All	III,IV	−0.532	<.001	6	view →
LUSC	All	All	−0.321	<.001	6	view →
CHOL	All	All	+0.686	<.001	4	view →
KICH	Female	All	−0.686	<.001	3	view →
THCA	All	All	−0.285	<.001	3	view →
BLCA	Male	IV	−0.565	.010	2	view →
KIRP	All	All	−0.456	.001	2	view →
HNSC	All	III,IV	+0.125	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PGM5P2–KIRC

Open the KIRC breakdown →