PGM5

Across TCGA patient cohorts, PGM5 mutation is significantly associated with the RNA expression of many other genes, with 1,301 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGM5-associated genes across cancer lineages are VN1R88P, VN1R87P, and RASSF1-AS1. Each is linked with PGM5 in more than 3 cancer types. Because this analysis shows association rather than direction, both PGM5-to-partner and partner-to-PGM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R88P grouped by PGM5-low versus PGM5-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGM5→partner) and Y-score (partner→PGM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	VN1R88P →	+0.643	+4.099	<.001	<.001	3	3
LUAD	VN1R87P →	+0.276	+2.468	<.001	.009	3	3
UCEC	RASSF1-AS1 →	+0.442	+3.213	<.001	.009	2	4
LUSC	EEF1A1P40 →	+0.122	+4.116	<.001	.009	3	3
SKCM	LINC01392 →	+0.053	+3.224	<.001	.001	3	3
HNSC	RNU6-129P →	+0.215	+4.424	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,301 associations by consensus.

VN1R88P by PGM5 expression — LUAD

Explore this box plot interactively →