Across TCGA pan-cancer cohorts, PGM5-AS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PGM5-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PGM5-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PGM5-AS1 is over-expressed in tumor, although a few such as BLCA and KIRC show the opposite, repressed pattern.

BLCA, KIRC, and COAD are the cancer types where PGM5-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PGM5-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−7.080	<.001	12	view →
KIRC	Male	IV	−1.247	<.001	12	view →
COAD	Male	II,III,IV	−2.769	<.001	11	view →
THCA	Female	III,IV	−1.363	<.001	11	view →
HNSC	Male	All	−0.408	<.001	10	view →
LUSC	All	III,IV	−1.714	<.001	9	view →
LUAD	Female	III,IV	−1.345	<.001	9	view →
UCEC	All	III,IV	−4.217	<.001	8	view →
STAD	Female	All	−4.060	<.001	8	view →
KICH	All	III,IV	−1.534	<.001	8	view →
READ	All	All	−3.668	<.001	7	view →
BRCA	All	III,IV	−2.101	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

Exploration

Same gene, other analysis: PGM5-AS1 RNA expression & survival · all PGM5-AS1 data types