PGM2L1

Across TCGA patient cohorts, PGM2L1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGM2L1-associated genes across cancer lineages are FoxM1, TFRC, and 14-3-3_beta. Each is linked with PGM2L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGM2L1-to-partner and partner-to-PGM2L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by PGM2L1-low versus PGM2L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGM2L1→partner) and Y-score (partner→PGM2L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.244	+2.469	.007	.010	3	2
UCEC	TFRC →	+0.451	+1.662	.016	.011	3	2
UCEC	14-3-3_beta →	-0.092	-2.432	.009	.018	3	1
UCEC	EGFR_pY1068 →	-0.306	-3.000	<.001	<.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.096	-1.990	.028	.009	3	1
UCEC	ACC_pS79 →	+0.260	+1.662	.034	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

FoxM1 by PGM2L1 expression — UCEC

Explore this box plot interactively →