PGM2

Across TCGA patient cohorts, PGM2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGM2-associated genes across cancer lineages are PCNA, A-Raf_pS299, and Cyclin-B1. Each is linked with PGM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PGM2-to-partner and partner-to-PGM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PGM2-low versus PGM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGM2→partner) and Y-score (partner→PGM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.191	+1.847	.016	.008	3	3
UCEC	A-Raf_pS299 →	-0.118	-2.115	.007	.017	3	2
UCEC	Cyclin-B1 →	+0.655	+3.459	.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.233	-1.847	.011	.008	3	1
UCEC	Heregulin →	-0.108	-1.584	.016	.034	3	1
UCEC	JNK2 →	+0.254	+3.486	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

PCNA by PGM2 expression — UCEC

Explore this box plot interactively →