PGM1

Across TCGA patient cohorts, PGM1 mutation is significantly associated with the RNA expression of many other genes, with 3,900 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGM1-associated genes across cancer lineages are NPAP1P2, FEN1, and PPP2R2D. Each is linked with PGM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PGM1-to-partner and partner-to-PGM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPAP1P2 grouped by PGM1-low versus PGM1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGM1→partner) and Y-score (partner→PGM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NPAP1P2 →	+0.021	+2.578	<.001	.003	3	3
UCEC	FEN1 →	+0.779	+2.254	<.001	<.001	3	3
UCEC	PPP2R2D →	+0.295	+3.970	<.001	<.001	3	3
UCEC	KCTD9 →	+0.580	+2.928	<.001	<.001	3	3
UCEC	FAF2 →	+0.345	+1.721	.001	.001	3	3
UCEC	PPP2CA →	+0.298	+2.296	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,900 associations by consensus.

NPAP1P2 by PGM1 expression — SKCM

Explore this box plot interactively →