PGM1

Across TCGA patient cohorts, PGM1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGM1-associated genes across cancer lineages are JNK_pT183_Y185, PDCD4, and VHL. Each is linked with PGM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGM1-to-partner and partner-to-PGM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by PGM1-low versus PGM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGM1→partner) and Y-score (partner→PGM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.210	-2.906	<.001	.001	3	2
UCEC	PDCD4 →	-0.519	-2.736	.002	<.001	3	2
UCEC	VHL →	-0.937	-2.000	<.001	.009	3	2
UCEC	Bcl-2 →	-0.379	-2.680	.002	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.579	+1.505	.007	.034	3	2
UCEC	c-Met_pY1235 →	+0.070	+1.710	.010	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

JNK_pT183_Y185 by PGM1 expression — UCEC

Explore this box plot interactively →