PGM1

Across TCGA cell cohorts, PGM1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PGM1-associated genes across cancer lineages are EDDM3B, ACER1, and UTF1. Each is linked with PGM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGM1-to-partner and partner-to-PGM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EDDM3B grouped by PGM1-low versus PGM1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGM1→partner) and Y-score (partner→PGM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	EDDM3B →	+0.023	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ACER1 →	+0.098	+3.823	.001	.006	3	1
LUNG_NSCLC_LUAD	UTF1 →	+0.605	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR2L8 →	+0.015	+5.266	<.001	.001	3	1
BLOOD_Leukemia	OR10T2 →	+1.072	+4.276	<.001	.007	3	1
BLOOD_Leukemia	OR10R2 →	+2.014	+4.551	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

EDDM3B by PGM1 expression — SKIN

Explore this box plot interactively →