PGLYRP4

Across TCGA patient cohorts, PGLYRP4 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGLYRP4-associated genes across cancer lineages are CD49b, Notch1, and STAT3_pY705. Each is linked with PGLYRP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGLYRP4-to-partner and partner-to-PGLYRP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD49b grouped by PGLYRP4-low versus PGLYRP4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGLYRP4→partner) and Y-score (partner→PGLYRP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CD49b →	-0.248	-2.683	.018	.006	3	2
UCEC	Notch1 →	+0.195	+2.125	<.001	.010	3	2
UCEC	STAT3_pY705 →	-0.436	-2.105	<.001	.017	3	2
UCEC	STAT5a →	+0.328	+1.807	.046	.027	3	2
UCEC	Cyclin-E2 →	+0.150	+1.874	.031	.049	3	2
SKCM	Akt_pS473 →	-0.506	-2.459	.038	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

CD49b by PGLYRP4 expression — SKCM

Explore this box plot interactively →