PGLYRP4

Across TCGA cell cohorts, PGLYRP4 protein abundance is significantly associated with the drug of many other genes, with 106 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PGLYRP4-associated genes across cancer lineages are Afatinib, Oxaliplatin, and Lapatinib. Each is linked with PGLYRP4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PGLYRP4-to-partner and partner-to-PGLYRP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Afatinib grouped by PGLYRP4-low versus PGLYRP4-high in BREAST.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGLYRP4→partner) and Y-score (partner→PGLYRP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Afatinib →	+1.444	+2.740	.015	.002	3	4
LUNG_NSCLC_LUSC	Oxaliplatin →	+0.379	+1.910	<.001	.032	3	3
SKIN	Lapatinib →	+1.630	+0.970	.025	.016	3	3
SKIN	Osimertinib →	+0.863	+0.970	.022	.016	3	3
BREAST	Ibrutinib →	+1.450	+2.740	.044	.002	3	3
BREAST	AST-1306 →	+0.416	+2.046	.018	.014	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

Afatinib by PGLYRP4 expression — BREAST

Explore this box plot interactively →