PGLYRP3

Across TCGA patient cohorts, PGLYRP3 mutation is significantly associated with the RNA expression of many other genes, with 635 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGLYRP3-associated genes across cancer lineages are TRAJ46, LRRC6P1, and NAGPA-AS1. Each is linked with PGLYRP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PGLYRP3-to-partner and partner-to-PGLYRP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ46 grouped by PGLYRP3-low versus PGLYRP3-high in SARC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGLYRP3→partner) and Y-score (partner→PGLYRP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	TRAJ46 →	+0.974	+5.224	<.001	.006	3	3
LIHC	LRRC6P1 →	+0.052	+6.902	<.001	<.001	3	2
LIHC	NAGPA-AS1 →	+0.079	+6.008	<.001	.002	3	2
SKCM	HYKK →	+0.383	+2.019	.001	.001	3	2
SKCM	RNU1-49P →	+0.114	+3.119	<.001	.004	3	2
SKCM	RN7SL300P →	+0.115	+1.881	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 635 associations by consensus.

TRAJ46 by PGLYRP3 expression — SARC

Explore this box plot interactively →