PGLYRP3

Across TCGA patient cohorts, PGLYRP3 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PGLYRP3-associated genes across cancer lineages are XBP1, PDCD4, and EGFR. Each is linked with PGLYRP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGLYRP3-to-partner and partner-to-PGLYRP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XBP1 grouped by PGLYRP3-low versus PGLYRP3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGLYRP3→partner) and Y-score (partner→PGLYRP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	XBP1 →	-0.205	-1.584	.032	.035	3	2
UCEC	PDCD4 →	-0.526	-2.321	.026	.035	3	2
SKCM	EGFR →	-0.135	-1.584	.034	.035	3	1
SKCM	ERK2 →	-0.176	-2.000	.032	.029	3	1
SKCM	GATA3 →	-0.189	-2.459	.011	.018	3	1
SKCM	Myosin-IIa →	-0.233	-2.977	.032	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

XBP1 by PGLYRP3 expression — SKCM

Explore this box plot interactively →