PGLYRP3

Across TCGA cell cohorts, PGLYRP3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PGLYRP3-associated genes across cancer lineages are NPVF, GLYATL3, and KLF18. Each is linked with PGLYRP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGLYRP3-to-partner and partner-to-PGLYRP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPVF grouped by PGLYRP3-low versus PGLYRP3-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGLYRP3→partner) and Y-score (partner→PGLYRP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NPVF →	+0.020	+5.000	<.001	.005	3	1
KIDNEY	GLYATL3 →	+0.043	+5.000	<.001	.005	3	1
KIDNEY	KLF18 →	+0.006	+5.000	<.001	.005	3	1
LARGE_INTESTINE	IQCF5 →	+0.025	+4.022	<.001	.006	3	1
SKIN	CCL11 →	+0.358	+3.920	<.001	.005	3	1
SKIN	OR2V1 →	+0.009	+4.217	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

NPVF by PGLYRP3 expression — KIDNEY

Explore this box plot interactively →