PGLYRP2

Across TCGA patient cohorts, PGLYRP2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGLYRP2-associated genes across cancer lineages are MSH6, ATM, and c-Kit. Each is linked with PGLYRP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGLYRP2-to-partner and partner-to-PGLYRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by PGLYRP2-low versus PGLYRP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGLYRP2→partner) and Y-score (partner→PGLYRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.299	-2.222	.007	.009	3	2
COAD	ATM →	-0.567	-3.161	.003	.019	3	2
UCEC	c-Kit →	-0.193	-1.807	.015	.004	3	2
UCEC	4E-BP1 →	+0.184	+1.874	.046	.049	3	2
UCEC	Cyclin-B1 →	+0.454	+1.807	.017	.004	3	2
UCEC	14-3-3_beta →	-0.096	-2.673	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MSH6 by PGLYRP2 expression — UCEC

Explore this box plot interactively →