PGLYRP2

Across TCGA cell cohorts, PGLYRP2 mutation is significantly associated with the RNA expression of many other genes, with 265 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PGLYRP2-associated genes across cancer lineages are SPINK9, APLNR, and RTP5. Each is linked with PGLYRP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGLYRP2-to-partner and partner-to-PGLYRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINK9 grouped by PGLYRP2-low versus PGLYRP2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGLYRP2→partner) and Y-score (partner→PGLYRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SPINK9 →	+0.058	+4.321	<.001	.009	3	2
LUNG_SCLC	APLNR →	+0.349	+3.762	.001	.003	3	1
CNS	RTP5 →	+0.062	+4.315	<.001	.006	3	1
STOMACH	SKOR2 →	+0.023	+5.285	<.001	.003	3	1
STOMACH	PRAMEF4 →	+0.006	+5.285	<.001	.003	3	1
LARGE_INTESTINE	CBY1 →	+0.701	+3.299	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 265 associations by consensus.

SPINK9 by PGLYRP2 expression — CNS

Explore this box plot interactively →