PGLS

Across TCGA patient cohorts, PGLS protein abundance is significantly associated with the RNA expression of many other genes, with 14,406 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PGLS-associated genes across cancer lineages are SLC27A1, SMIM7, and AQP9. Each is linked with PGLS in more than 5 cancer types. Because this analysis shows association rather than direction, both PGLS-to-partner and partner-to-PGLS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PGLS versus SLC27A1 in OV, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGLS→partner) and Y-score (partner→PGLS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SLC27A1 →	+0.615	+0.357	<.001	<.001	3	6
OV	SMIM7 →	+0.666	+0.601	<.001	<.001	3	6
HNSC	AQP9 →	-1.240	-0.303	<.001	.001	3	5
HNSC	TRIP13 →	-0.703	-0.216	.003	.002	3	5
OV	C19orf44 →	+0.529	+0.347	<.001	<.001	3	4
LUAD	KXD1 →	+0.360	+0.179	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,406 associations by consensus.

PGLS vs SLC27A1 — OV

Explore this scatter interactively →