PGLS

Across TCGA cell cohorts, PGLS RNA expression is significantly associated with the RNA expression of many other genes, with 7,287 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PGLS-associated genes across cancer lineages are TRIR, MVB12A, and COPE. Each is linked with PGLS in more than 15 cancer types. Because this analysis shows association rather than direction, both PGLS-to-partner and partner-to-PGLS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PGLS versus TRIR in BONE, with a Pearson correlation of 0.54.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGLS→partner) and Y-score (partner→PGLS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TRIR →	+0.889	+0.705	<.001	<.001	3	16
LUNG_NSCLC_LUSC	MVB12A →	+1.061	+1.229	.004	<.001	2	15
BREAST	COPE →	+0.733	+0.739	<.001	<.001	3	14
LUNG_NSCLC_LUSC	RFXANK →	+1.020	+1.008	.006	.002	1	15
BONE	CRTC1 →	+1.269	+0.942	<.001	<.001	3	13
OESOPHAGUS	JUND →	+1.584	+0.849	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,287 associations by consensus.

PGLS vs TRIR — BONE

Explore this scatter interactively →