PGLS

Across TCGA cell cohorts, PGLS RNA expression is significantly associated with the go_rna of many other GO terms, with 2,997 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PGLS-associated GO terms across cancer lineages are Pentose-phosphate shunt, oxidative branch, Flagellated sperm motility, and Sperm motility. Each is linked with PGLS in more than 15 cancer types. Because this analysis shows association rather than direction, both PGLS-to-partner and partner-to-PGLS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pentose-phosphate shunt, oxidative branch grouped by PGLS-low versus PGLS-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PGLS→partner) and Y-score (partner→PGLS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Pentose-phosphate shunt, oxidative branch →	+0.163	+0.968	<.001	<.001	3	16
SOFT_TISSUE	Flagellated sperm motility →	-0.071	-0.777	<.001	<.001	3	13
SOFT_TISSUE	Sperm motility →	-0.071	-0.777	<.001	<.001	3	13
SOFT_TISSUE	Cilium movement involved in cell motility →	-0.075	-0.836	.002	<.001	3	10
SOFT_TISSUE	Fatty acid oxidation →	+0.066	+0.954	.002	.001	3	10
SOFT_TISSUE	Negative regulation of inflammasome-mediated signaling pathway →	+0.132	+1.044	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,997 associations by consensus.

Pentose-phosphate shunt, oxidative branch by PGLS expression — LUNG_SCLC

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