PGK1

Across TCGA pan-cancer cohorts, PGK1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PGK1 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PGK1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PGK1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LUAD, CCRCC, and HNSC are the cancer types where PGK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.420	0.769	.001	62	view →
CCRCC	OS	Tertile	III,IV	0.985	0.104	.024	8	view →
HNSC	DFS	Quartile	III,IV	0.939	0.692	.015	4	view →
GBM	OS	Quartile	All	0.269	0.625	.029	3	view →
LSCC	DFS	Median	II,III,IV	0.884	0.681	.025	3	view →
PDAC	DFS	Median	III,IV	0.492	0.833	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PGK1–LUAD (DFS)

Open the LUAD breakdown →