PGK1

Across TCGA patient cohorts, PGK1 mutation is significantly associated with the RNA expression of many other genes, with 1,890 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGK1-associated genes across cancer lineages are FGF21, RPL31P1, and MIR4266. Each is linked with PGK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGK1-to-partner and partner-to-PGK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF21 grouped by PGK1-low versus PGK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGK1→partner) and Y-score (partner→PGK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FGF21 →	+0.321	+1.791	.001	.004	3	2
BRCA	RPL31P1 →	+0.091	+4.575	<.001	.009	3	2
LUAD	MIR4266 →	+0.265	+4.315	.002	.007	3	2
UCEC	RNA5SP412 →	+0.385	+1.645	.002	.008	3	2
UCEC	LINC00463 →	+0.102	+1.606	.001	.005	3	2
UCEC	RNA5SP413 →	+0.907	+1.649	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,890 associations by consensus.

FGF21 by PGK1 expression — UCEC

Explore this box plot interactively →