PGGT1B

Across TCGA patient cohorts, PGGT1B protein abundance is significantly associated with the RNA expression of many other genes, with 9,303 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PGGT1B-associated genes across cancer lineages are XPO1, BRMS1L, and VNN2. Each is linked with PGGT1B in more than 4 cancer types. Because this analysis shows association rather than direction, both PGGT1B-to-partner and partner-to-PGGT1B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PGGT1B versus XPO1 in LSCC, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGGT1B→partner) and Y-score (partner→PGGT1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	XPO1 →	-0.576	-0.213	<.001	.001	3	5
LSCC	BRMS1L →	-0.675	-0.188	<.001	.008	3	4
UCEC	VNN2 →	+1.182	+0.217	<.001	<.001	3	4
GBM	TROAP →	-1.247	-0.289	<.001	<.001	3	4
HNSC	TJAP1 →	-0.491	-0.236	.001	<.001	3	4
LSCC	MMS22L →	-0.715	-0.228	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,303 associations by consensus.

PGGT1B vs XPO1 — LSCC

Explore this scatter interactively →