PGGT1B

Across TCGA patient cohorts, PGGT1B mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGGT1B-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and FoxM1. Each is linked with PGGT1B in more than 1 cancer types. Because this analysis shows association rather than direction, both PGGT1B-to-partner and partner-to-PGGT1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PGGT1B-low versus PGGT1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGGT1B→partner) and Y-score (partner→PGGT1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.223	-1.807	.031	.027	3	1
UCEC	A-Raf_pS299 →	-0.131	-3.000	.007	.036	3	1
UCEC	FoxM1 →	+0.298	+3.000	.005	.001	3	1
UCEC	GATA6 →	-0.185	-3.155	.006	.018	3	1
UCEC	ACVRL1 →	-0.150	-1.807	.007	.027	3	1
UCEC	JNK_pT183_Y185 →	-0.194	-3.321	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

EGFR_pY1068 by PGGT1B expression — UCEC

Explore this box plot interactively →