PGGT1B

Across TCGA cell cohorts, PGGT1B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,350 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PGGT1B-associated GO terms across cancer lineages are CAAX-box protein maturation, Double-strand break repair via nonhomologous end joining, and Nuclear envelope organization. Each is linked with PGGT1B in more than 19 cancer types. Because this analysis shows association rather than direction, both PGGT1B-to-partner and partner-to-PGGT1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CAAX-box protein maturation grouped by PGGT1B-low versus PGGT1B-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PGGT1B→partner) and Y-score (partner→PGGT1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CAAX-box protein maturation →	+0.148	+0.892	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via nonhomologous end joining →	+0.052	+0.797	.001	.004	3	14
LUNG_NSCLC_LUAD	Nuclear envelope organization →	+0.051	+0.491	.001	.002	3	14
LARGE_INTESTINE	Endosomal transport →	+0.050	+0.877	<.001	.001	3	13
SOFT_TISSUE	Negative regulation of microtubule depolymerization →	+0.105	+0.840	<.001	.003	3	13
SKIN	Regulation of chromosome organization →	+0.070	+0.725	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,350 associations by consensus.

CAAX-box protein maturation by PGGT1B expression — LIVER

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