PGGHG

Across TCGA patient cohorts, PGGHG mutation is significantly associated with the RNA expression of many other genes, with 4,466 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGGHG-associated genes across cancer lineages are C18orf54, AP4E1, and KLHL2. Each is linked with PGGHG in more than 2 cancer types. Because this analysis shows association rather than direction, both PGGHG-to-partner and partner-to-PGGHG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C18orf54 grouped by PGGHG-low versus PGGHG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGGHG→partner) and Y-score (partner→PGGHG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C18orf54 →	+0.412	+1.643	.007	.003	3	3
UCEC	AP4E1 →	+0.457	+2.922	<.001	<.001	3	3
UCEC	KLHL2 →	+0.488	+2.447	.001	.001	3	3
UCEC	DHDDS →	+0.358	+1.903	<.001	<.001	3	3
SKCM	RNU6-891P →	+0.267	+3.110	<.001	.001	3	2
SKCM	TPT1P13 →	+0.377	+3.240	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,466 associations by consensus.

C18orf54 by PGGHG expression — UCEC

Explore this box plot interactively →