PGGHG

Across TCGA patient cohorts, PGGHG mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGGHG-associated genes across cancer lineages are PCNA, ATM, and 4E-BP1. Each is linked with PGGHG in more than 1 cancer types. Because this analysis shows association rather than direction, both PGGHG-to-partner and partner-to-PGGHG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PGGHG-low versus PGGHG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGGHG→partner) and Y-score (partner→PGGHG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.165	+1.459	.018	.012	3	2
UCEC	ATM →	-0.390	-1.222	.008	.035	3	2
UCEC	4E-BP1 →	+0.251	+1.707	.004	.012	3	2
UCEC	C-Raf →	+0.155	+1.925	<.001	.004	3	2
UCEC	Cyclin-B1 →	+0.465	+1.459	.010	.012	3	2
UCEC	EGFR_pY1068 →	-0.228	-2.321	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

PCNA by PGGHG expression — UCEC

Explore this box plot interactively →