PGF

Across TCGA cell cohorts, PGF mutation is significantly associated with the mutation status of many other genes, with 1,517 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PGF-associated genes across cancer lineages are TUBA3D, CFHR4, and TARS2. Each is linked with PGF in more than 1 cancer types. Because this analysis shows association rather than direction, both PGF-to-partner and partner-to-PGF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBA3D grouped by PGF-low versus PGF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGF→partner) and Y-score (partner→PGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TUBA3D →	+4.087	+5.044	.001	.001	1	2
LARGE_INTESTINE	CFHR4 →	+4.672	+5.329	<.001	<.001	1	2
LARGE_INTESTINE	TARS2 →	+3.350	+4.584	.003	.003	1	2
LARGE_INTESTINE	DTL →	+3.087	+4.392	.005	.005	1	2
LARGE_INTESTINE	ACAD8 →	+4.087	+5.044	.001	.001	1	2
LARGE_INTESTINE	ZDHHC7 →	+3.087	+4.392	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,517 associations by consensus.

TUBA3D by PGF expression — LARGE_INTESTINE

Explore this box plot interactively →