PGC

Across TCGA patient cohorts, PGC protein abundance is significantly associated with the RNA expression of many other genes, with 7,311 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PGC-associated genes across cancer lineages are NR0B2, CREB3L1, and KCNQ1. Each is linked with PGC in more than 2 cancer types. Because this analysis shows association rather than direction, both PGC-to-partner and partner-to-PGC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PGC versus NR0B2 in PDAC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGC→partner) and Y-score (partner→PGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	NR0B2 →	+1.092	+0.892	<.001	.004	3	3
LSCC	CREB3L1 →	+0.840	+0.691	<.001	<.001	3	3
LSCC	KCNQ1 →	+0.634	+0.713	<.001	<.001	3	3
PDAC	CLDN18 →	+2.322	+1.214	<.001	<.001	3	3
LSCC	TMC5 →	+1.132	+0.748	<.001	<.001	3	2
PDAC	PIP5K1B →	+0.872	+1.069	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,311 associations by consensus.

PGC vs NR0B2 — PDAC

Explore this scatter interactively →