PGC

Across TCGA patient cohorts, PGC mutation is significantly associated with the RNA expression of many other genes, with 3,661 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGC-associated genes across cancer lineages are RN7SL504P, RNU6-517P, and RNU6-1198P. Each is linked with PGC in more than 2 cancer types. Because this analysis shows association rather than direction, both PGC-to-partner and partner-to-PGC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL504P grouped by PGC-low versus PGC-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGC→partner) and Y-score (partner→PGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL504P →	+0.032	+3.784	<.001	.009	3	3
HNSC	RNU6-517P →	+0.375	+5.124	<.001	.008	3	3
SKCM	RNU6-1198P →	+0.271	+2.923	<.001	.001	3	2
SKCM	MIR4510 →	+0.090	+3.784	<.001	.009	3	2
SKCM	NDUFA7 →	+0.445	+2.535	<.001	.009	3	2
BLCA	RNA5SP308 →	+0.431	+5.618	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,661 associations by consensus.

RN7SL504P by PGC expression — SKCM

Explore this box plot interactively →