PGC

Across TCGA patient cohorts, PGC mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGC-associated genes across cancer lineages are eEF2, ATM, and Caspase-7-cleavedD198. Each is linked with PGC in more than 1 cancer types. Because this analysis shows association rather than direction, both PGC-to-partner and partner-to-PGC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PGC-low versus PGC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGC→partner) and Y-score (partner→PGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.375	+2.415	.009	.003	3	2
UCEC	ATM →	-0.634	-3.700	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.691	+2.479	.003	.010	3	2
SKCM	Caveolin-1 →	-0.854	-3.000	.016	.036	3	1
UCEC	14-3-3_beta →	-0.106	-2.295	.008	.033	3	1
UCEC	FoxM1 →	+0.249	+2.415	.016	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

eEF2 by PGC expression — UCEC

Explore this box plot interactively →