Across TCGA patient cohorts, PGBD2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGBD2-associated genes across cancer lineages are 4E-BP1, 14-3-3_beta, and eIF4E. Each is linked with PGBD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGBD2-to-partner and partner-to-PGBD2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGBD2→partner) and Y-score (partner→PGBD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.268	+1.807	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.070	-1.253	.019	.049	3	1
UCEC	eIF4E →	+0.163	+2.169	.009	.003	3	1
UCEC	FASN →	+0.311	+1.440	.008	.022	3	1
UCEC	GATA6 →	-0.097	-2.100	.046	.016	3	1
UCEC	Heregulin →	-0.097	-2.308	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

PGBD2 survival (RNA) · tumor vs normal (RNA) · all PGBD2 data types