PGBD1

Across TCGA cell cohorts, PGBD1 mutation is significantly associated with the mutation status of many other genes, with 1,814 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PGBD1-associated genes across cancer lineages are SLC6A1, INO80D, and TRERF1. Each is linked with PGBD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PGBD1-to-partner and partner-to-PGBD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC6A1 grouped by PGBD1-low versus PGBD1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGBD1→partner) and Y-score (partner→PGBD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC6A1 →	+5.014	+5.584	.003	.003	1	4
BLOOD_Lymphoma	INO80D →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	TRERF1 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Leukemia	CASD1 →	+4.479	+5.635	<.001	<.001	1	3
LARGE_INTESTINE	FN1 →	+1.707	+2.991	.002	.002	1	3
LARGE_INTESTINE	TEX10 →	+2.544	+2.793	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,814 associations by consensus.

SLC6A1 by PGBD1 expression — BLOOD_Lymphoma

Explore this box plot interactively →