PGBD1

Across TCGA cell cohorts, PGBD1 mutation is significantly associated with the drug of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PGBD1-associated genes across cancer lineages are Motesanib, FEN1_3940, and Cyclophosphamide. Each is linked with PGBD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGBD1-to-partner and partner-to-PGBD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Motesanib grouped by PGBD1-low versus PGBD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGBD1→partner) and Y-score (partner→PGBD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Motesanib →	+0.314	+3.000	.032	.021	3	1
LARGE_INTESTINE	FEN1_3940 →	-0.506	-2.935	.039	.021	3	1
LARGE_INTESTINE	Cyclophosphamide →	+0.322	+3.064	.022	.009	3	1
LARGE_INTESTINE	QL-XII-47 →	-0.602	-2.740	.044	.045	3	1
LARGE_INTESTINE	Voxtalisib →	+0.271	+2.874	.042	.021	3	1
LARGE_INTESTINE	Bosutinib →	+0.365	+3.000	.032	.021	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Motesanib by PGBD1 expression — LARGE_INTESTINE

Explore this box plot interactively →