PGAP4

Across TCGA patient cohorts, PGAP4 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGAP4-associated genes across cancer lineages are FOXO3a_pS318_S321, mTOR_pS2448, and PCNA. Each is linked with PGAP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGAP4-to-partner and partner-to-PGAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by PGAP4-low versus PGAP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAP4→partner) and Y-score (partner→PGAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.102	-1.584	.018	.032	3	2
UCEC	mTOR_pS2448 →	-0.126	-1.980	.014	.030	3	2
UCEC	PCNA →	+0.222	+2.459	.003	<.001	3	2
UCEC	VHL →	-1.316	-2.938	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.632	+2.070	.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.247	-2.459	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

FOXO3a_pS318_S321 by PGAP4 expression — UCEC

Explore this box plot interactively →