PGAP4

Across TCGA cell cohorts, PGAP4 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PGAP4-associated genes across cancer lineages are IRGC, URAD, and IFNA10. Each is linked with PGAP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGAP4-to-partner and partner-to-PGAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRGC grouped by PGAP4-low versus PGAP4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAP4→partner) and Y-score (partner→PGAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	IRGC →	+0.028	+3.866	.001	.006	3	1
CNS	URAD →	+0.011	+4.169	.001	.008	3	1
CNS	IFNA10 →	+0.202	+4.285	<.001	.001	3	1
CNS	IFNA7 →	+0.131	+4.772	<.001	.002	3	1
CNS	IFNA4 →	+0.149	+4.906	<.001	<.001	3	1
BREAST	OR2G6 →	+0.016	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

IRGC by PGAP4 expression — CNS

Explore this box plot interactively →