Across TCGA pan-cancer cohorts, PGAP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PGAP1 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PGAP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PGAP1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

UCEC, LSCC, and LUAD are the cancer types where PGAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.287	0.904	.017	16	view →
LSCC	DFS	Tertile	All	0.970	0.871	.016	2	view →
LUAD	DFS	Quartile	II,III,IV	0.422	0.761	.029	2	view →
PDAC	OS	Median	III,IV	0.954	0.583	.019	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PGAP1 tumor-vs-normal RNA expression · all PGAP1 data types