Across TCGA patient cohorts, PGAP1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,465 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PGAP1-associated genes across cancer lineages are ARHGAP35, SIPA1L2, and ACVR2A. Each is linked with PGAP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PGAP1-to-partner and partner-to-PGAP1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAP1→partner) and Y-score (partner→PGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ARHGAP35 →	+0.784	+0.539	<.001	<.001	3	5
LSCC	SIPA1L2 →	+1.025	+0.765	<.001	<.001	3	4
OV	ACVR2A →	+0.618	+0.404	<.001	.001	3	4
HNSC	NTRK2 →	+3.111	+1.126	<.001	<.001	3	4
OV	SETBP1 →	+0.837	+0.405	<.001	<.001	3	4
HNSC	IRF2BP1 →	+0.949	+0.782	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,465 associations by consensus.

Exploration

PGAP1 survival (RNA) · tumor vs normal (RNA) · all PGAP1 data types