PGAP1

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PGAP1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGAP1-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and HER2_pY1248. Each is linked with PGAP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PGAP1-to-partner and partner-to-PGAP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAP1→partner) and Y-score (partner→PGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCaspase-7-cleavedD198 →+0.436+1.543.010.00433
UCECEGFR_pY1068 →-0.274-2.321<.001<.00132
UCECHER2_pY1248 →-0.174-1.736.023<.00132
UCECJNK_pT183_Y185 →-0.137-1.459.004.01132
UCECRab25 →-0.324-1.736<.001<.00132
UCECSTAT3_pY705 →-0.357-1.874<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

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