Across TCGA cell cohorts, PGAP1 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PGAP1-associated genes across cancer lineages are IQCF5, PPDPFL, and ARGFX. Each is linked with PGAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGAP1-to-partner and partner-to-PGAP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAP1→partner) and Y-score (partner→PGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.056	+5.357	<.001	.003	3	1
LARGE_INTESTINE	PPDPFL →	+0.034	+3.217	<.001	.006	3	1
LARGE_INTESTINE	ARGFX →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	SCYGR2 →	+0.037	+3.700	<.001	.009	3	1
LUNG_NSCLC_LUAD	FGF6 →	+0.225	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	USP29 →	+0.016	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

PGAP1 survival (RNA) · tumor vs normal (RNA) · all PGAP1 data types