Across TCGA pan-cancer cohorts, PGAM4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PGAM4 data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PGAM4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PGAM4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SKCM, UCEC, and CESC are the cancer types where PGAM4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	III,IV	0.016	0.648	<.001	12	view →
UCEC	DFS	Median	All	1.000	0.830	.027	8	view →
CESC	DFS	Median	All	0.260	0.740	.042	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: PGAM4 tumor-vs-normal RNA expression · all PGAM4 data types