Across TCGA patient cohorts, PGAM4 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGAM4-associated genes across cancer lineages are eIF4E, ERK2, and JNK2. Each is linked with PGAM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGAM4-to-partner and partner-to-PGAM4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAM4→partner) and Y-score (partner→PGAM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.217	+3.183	.010	.009	3	1
UCEC	ERK2 →	+0.212	+3.459	.006	.005	3	1
UCEC	JNK2 →	+0.301	+2.415	<.001	.003	3	1
UCEC	MEK1 →	+0.522	+3.087	<.001	<.001	3	1
UCEC	MSH2 →	-0.314	-3.295	<.001	.009	3	1
UCEC	Myosin-IIa →	+0.194	+2.229	.013	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

PGAM4 survival (RNA) · tumor vs normal (RNA) · all PGAM4 data types