PGAM2

Across TCGA cell cohorts, PGAM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,293 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PGAM2-associated GO terms across cancer lineages are Positive regulation of signal transduction by p53 class mediator, Positive regulation of triglyceride storage, and Positive regulation of dopamine metabolic process. Each is linked with PGAM2 in more than 6 cancer types. Because this analysis shows association rather than direction, both PGAM2-to-partner and partner-to-PGAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of signal transduction by p53 class mediator grouped by PGAM2-low versus PGAM2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAM2→partner) and Y-score (partner→PGAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of signal transduction by p53 class mediator →	+0.088	+3.017	.003	<.001	2	7
LUNG_SCLC	Positive regulation of triglyceride storage →	-1.168	-2.427	<.001	<.001	3	6
CNS	Positive regulation of dopamine metabolic process →	-0.073	-0.578	.006	.007	3	6
OESOPHAGUS	Negative regulation of macroautophagy →	+0.061	+0.186	.006	.007	3	5
BLOOD_Leukemia	Response to nitric oxide →	-0.084	-0.277	<.001	.001	3	5
LUNG_SCLC	Regulation of triglyceride storage →	-1.267	-2.418	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,293 associations by consensus.

Positive regulation of signal transduction by p53 class mediator by PGAM2 expression — LUNG_SCLC

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