PGAM2

Across TCGA cell cohorts, PGAM2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PGAM2-associated genes across cancer lineages are ADAM2, KRTAP19-4, and GFRA4. Each is linked with PGAM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGAM2-to-partner and partner-to-PGAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM2 grouped by PGAM2-low versus PGAM2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAM2→partner) and Y-score (partner→PGAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ADAM2 →	+0.046	+5.754	<.001	.002	3	1
CNS	KRTAP19-4 →	+0.186	+5.754	<.001	.002	3	1
BLOOD_Leukemia	GFRA4 →	+0.308	+4.409	<.001	.005	3	1
BLOOD_Leukemia	CCKAR →	+0.043	+4.409	<.001	.005	3	1
BLOOD_Leukemia	OR10K2 →	+0.060	+4.705	<.001	.003	3	1
BLOOD_Leukemia	OR10T2 →	+0.889	+4.276	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ADAM2 by PGAM2 expression — CNS

Explore this box plot interactively →