PGAM1

Across TCGA pan-cancer cohorts, PGAM1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PGAM1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PGAM1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PGAM1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

COAD, LUAD, and PDAC are the cancer types where PGAM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.879	1.000	.018	54	view →
LUAD	OS	Median	All	0.727	0.945	<.001	32	view →
PDAC	DFS	Median	II,III,IV	0.683	0.870	.002	11	view →
CCRCC	DFS	Median	III,IV	0.928	0.128	.014	10	view →
HNSC	OS	Median	All	1.000	0.484	.038	6	view →
UCEC	DFS	Median	II,III,IV	0.867	0.534	.044	4	view →
LSCC	DFS	Quartile	II,III,IV	0.887	0.198	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PGAM1–COAD (DFS)

Open the COAD breakdown →