PGAM1

Across TCGA patient cohorts, PGAM1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGAM1-associated genes across cancer lineages are GATA3, GSK-3_pS9, and GSK-3a-b_pS21_S9. Each is linked with PGAM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGAM1-to-partner and partner-to-PGAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA3 grouped by PGAM1-low versus PGAM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAM1→partner) and Y-score (partner→PGAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA3 →	-0.297	-2.979	.006	.036	3	1
UCEC	GSK-3_pS9 →	+0.463	+3.000	.047	.037	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.542	+3.000	.028	.037	3	1
UCEC	Bcl-xL →	-0.191	-3.000	.039	.037	3	1
UCEC	G6PD →	-0.403	-3.000	.031	.037	2	1
UCEC	Tuberin →	+0.413	+2.817	.007	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

GATA3 by PGAM1 expression — UCEC

Explore this box plot interactively →