PGAM1

Across TCGA cell cohorts, PGAM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,812 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible PGAM1-associated GO terms across cancer lineages are Spindle elongation, Mitotic nuclear division, and Mitotic spindle midzone assembly. Each is linked with PGAM1 in more than 14 cancer types. Because this analysis shows association rather than direction, both PGAM1-to-partner and partner-to-PGAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spindle elongation grouped by PGAM1-low versus PGAM1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAM1→partner) and Y-score (partner→PGAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Spindle elongation →	+0.257	+1.037	.002	.001	3	15
PANCREAS	Mitotic nuclear division →	+0.086	+0.938	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Mitotic spindle midzone assembly →	+0.234	+0.898	.008	.007	2	15
SKIN	Canonical glycolysis →	+0.127	+0.746	<.001	<.001	3	14
SKIN	Glucose catabolic process to pyruvate →	+0.127	+0.746	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Mitotic spindle elongation →	+0.234	+0.898	.008	.007	2	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,812 associations by consensus.

Spindle elongation by PGAM1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →