PGA5

Across TCGA cell cohorts, PGA5 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,084 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PGA5-associated GO terms across cancer lineages are Regulatory ncRNA-mediated gene silencing, Heterochromatin formation, and Epigenetic regulation of gene expression. Each is linked with PGA5 in more than 5 cancer types. Because this analysis shows association rather than direction, both PGA5-to-partner and partner-to-PGA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulatory ncRNA-mediated gene silencing grouped by PGA5-low versus PGA5-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PGA5→partner) and Y-score (partner→PGA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulatory ncRNA-mediated gene silencing →	+0.051	+0.250	<.001	.006	3	5
BLOOD_Leukemia	Heterochromatin formation →	+0.035	+0.165	<.001	.001	3	5
BLOOD_Leukemia	Epigenetic regulation of gene expression →	+0.029	+0.185	<.001	<.001	3	5
BLOOD_Leukemia	Regulation of RNA stability →	+0.036	+0.157	<.001	.002	3	5
BLOOD_Leukemia	Negative regulation of gene expression, epigenetic →	+0.033	+0.173	<.001	.001	3	5
BLOOD_Leukemia	Regulation of mRNA processing →	+0.037	+0.182	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,084 associations by consensus.

Regulatory ncRNA-mediated gene silencing by PGA5 expression — BLOOD_Leukemia

Explore this box plot interactively →