PGA4

Across TCGA patient cohorts, PGA4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,682 significant associations in total. THCA shows the largest number of these associations.

The most reproducible PGA4-associated GO terms across cancer lineages are Regulation of blood pressure, Regulation of membrane depolarization during cardiac muscle cell action potential, and Sterol homeostasis. Each is linked with PGA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PGA4-to-partner and partner-to-PGA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of blood pressure grouped by PGA4-low versus PGA4-high in KIRC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PGA4→partner) and Y-score (partner→PGA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	Regulation of blood pressure →	+0.019	+0.017	<.001	<.001	3	4
THCA	Regulation of membrane depolarization during cardiac muscle cell action potential →	+0.029	+0.006	<.001	<.001	3	3
KIRC	Sterol homeostasis →	+0.017	+0.020	<.001	<.001	3	3
UCEC	Regulation of astrocyte activation →	-0.092	-0.001	.001	.005	3	3
KIRC	Cellular response to ammonium ion →	+0.086	+0.026	<.001	<.001	3	3
LIHC	Cellular response to hydroperoxide →	+0.058	+0.001	.003	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,682 associations by consensus.

Regulation of blood pressure by PGA4 expression — KIRC

Explore this box plot interactively →