PGA3

Across TCGA patient cohorts, PGA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,970 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible PGA3-associated GO terms across cancer lineages are Positive regulation of cytoskeleton organization, Developmental cell growth, and Astrocyte differentiation. Each is linked with PGA3 in more than 8 cancer types. Because this analysis shows association rather than direction, both PGA3-to-partner and partner-to-PGA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cytoskeleton organization grouped by PGA3-low versus PGA3-high in KIRP.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PGA3→partner) and Y-score (partner→PGA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	Positive regulation of cytoskeleton organization →	+0.025	+0.018	<.001	<.001	3	9
TGCT	Developmental cell growth →	+0.045	+0.007	<.001	<.001	3	8
LAML	Astrocyte differentiation →	+0.048	+0.129	<.001	.002	3	8
KIRP	Regulation of protein secretion →	+0.016	+0.026	<.001	<.001	3	8
TGCT	Regulation of canonical Wnt signaling pathway →	+0.051	+0.007	<.001	<.001	3	8
TGCT	Regulation of stress-activated protein kinase signaling cascade →	+0.023	+0.007	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,970 associations by consensus.

Positive regulation of cytoskeleton organization by PGA3 expression — KIRP

Explore this box plot interactively →