PFN4

Across TCGA cell cohorts, PFN4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,683 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible PFN4-associated GO terms across cancer lineages are Zinc ion import into lysosome, Action potential, and Nucleotide-excision repair. Each is linked with PFN4 in more than 8 cancer types. Because this analysis shows association rather than direction, both PFN4-to-partner and partner-to-PFN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Zinc ion import into lysosome grouped by PFN4-low versus PFN4-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PFN4→partner) and Y-score (partner→PFN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Zinc ion import into lysosome →	-0.319	-0.830	<.001	.003	3	9
STOMACH	Action potential →	-0.182	-0.975	<.001	<.001	3	7
BLOOD_Lymphoma	Nucleotide-excision repair →	+0.052	+0.496	<.001	.001	3	7
LUNG_NSCLC_LUAD	Mitotic cytokinesis →	+0.054	+0.613	<.001	.001	3	7
STOMACH	Regulation of intracellular transport →	+0.043	+0.617	.002	<.001	3	7
PANCREAS	Cellular response to water stimulus →	+0.108	+0.512	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,683 associations by consensus.

Zinc ion import into lysosome by PFN4 expression — STOMACH

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